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Canavan, Mary and McCarthy, Ciara and Ben Larbi, Nadia and Dowling, Jennifer and Collins, Laura and O'Sullivan, Finbarr and Hurley, Grainne and Murphy, Carola and Quinlan, Aoife and Moloney, Gerry and Darby, Trevor and MacSharry, John and Kagechika, Hiroyuki and Moynagh, Paul N. and Melgar, Silvia and Loscher, Christine E. (2013) Activation of liver X receptor suppresses the production of the IL-12 family of cytokines by blocking nuclear translocation of NF-kBp50. Innate Immunity. ISSN 1753-4259
O'Shea, D. and Corrigan, M. and Dunne, M.R. and Jackson, R. and Woods, C. and Gaoatswe, G. and Moynagh, Paul N. and O'Connell, J. and Hogan, A.E. (2013) Changes in human dendritic cell number and function in severe obesity may contribute to increased susceptibility to viral infection. International Journal of Obesity, 37 (11). pp. 1510-1513. ISSN 0307-0565
Doyle, Sarah L. and Shirey, Kari Ann and McGettrick, Anne F. and Kenny, Elaine F. and Carpenter, Susan B. and Caffrey, Brian E. and Gardan, Siobhan and Quinn, Susan R. and Cammano, Jorge H. and Moynagh, Paul N. and Vogel, Stefani N. and O'Neill, Luke A. (2013) NFκB2 p52 has a role in antiviral immunity through IKKε -dependent induction of Sp1 and IL-15. Journal of Biological Chemistry. ISSN 0021-9258
Yang, Shuo and Wang, Bingwei and Tang, Lisa S. and Siednienko, Jackub and Callanan, John J. and Moynagh, Paul N. (2013) Pellino3 targets RIP1 and regulates the pro-apoptotic effects of TNF-α. Nature Communications, 4 (2583). ISSN 2041-1723
Yang, Shuo and Wang, Bingwei and Humphries, Fiachra and Jackson, Ruaidhri and Healy, Mark and Bergin, Ronan and Aviello, Gabriella and Hall, Barry and McNamara, Deirdre and Darby, Trevor and Quinlan, Aoife and Shanahan, Fergus and Melgar, Silvia and Fallon, Padraic G. and Moynagh, Paul N. (2013) Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis. Nature Immunology, 14 (9). pp. 927-936. ISSN 1529-2908
Malynn, Sandra and Campos-Torres, Antonio and Moynagh, Paul N. and Haas, Jana (2013) The Pro-inflammatory Cytokine TNF-a Regulates the Activity and Expression of the Serotonin Transporter (SERT) in Astrocytes. Neurochemical Research, 38 (4). pp. 694-704. ISSN 0364-3190
O’Callaghan, Emma K. and Anderson, Sean T. and Moynagh, Paul N. and Coogan, Andrew N. (2012) Long-Lasting Effects of Sepsis on Circadian Rhythms in the Mouse. PLoS ONE, 7 (10 e47087). pp. 1-14. ISSN 1932-6203
Mellett, Mark and Atzei, Paola and Horgan, Alan and Hams, Emily and Floss, Thomas and Wurst, Wolfgang and Fallon, Padraic G. and Moynagh, Paul N. (2012) Orphan receptor IL-17RD tunes IL-17A signalling and is required for neutrophilia. Nature Communications, 3 (1119). ISSN 2041-1723
Siednienko, Jakcub and Jackson, Ruaidhri and Mellett, Mark and Delagic, Nezira and Yang, Shuo and Wang, Bingwei and Tang, Lisa S. and Callanan, John J. and Mahon, Bernard P. and Moynagh, Paul N. (2012) Pellino3 targets the IRF7 pathway and facilitates autoregulation of TLR3- and viral-induced expression of type I interferons. Nature Immunology, 13. pp. 1055-1062. ISSN 1529-2908
Downer, Eric J. and Clifford, Eileen and Amu, Sylvie and Fallon, Padraic G. and Moynagh, Paul N. (2012) The Synthetic Cannabinoid R(+)WIN55,212-2 Augments Interferon-β Expression via Peroxisome Proliferator-activated Receptor-α. Journal of Biological Chemistry, 287 (30). pp. 25440-25453. ISSN 0021-9258
Griffin, Bryan D. and Mellett, Mark and Campos-Torres, Antonio and Kinsella, Gemma K. and Wang, Bingwei and Moynagh, Paul N. (2011) A poxviral homolog of the Pellino protein inhibits Toll and Toll-like receptor signalling. European Journal of Immunology, 41 (3). pp. 798-812.
Hogan, A.E. and Tobin, A.M. and Ahern, T. and Corrigan, M.A. and Gaoatswe, G. and Jackson, R. and O’Reilly, V. and Lynch, L. and Doherty, D.G. and Moynagh, Paul N. and Kirby, B. and O’Connell, J. and O'Shea, D. (2011) Glucagon-like peptide-1 (GLP-1) and the regulation of human invariant natural killer Tcells: lessons from obesity, diabetes and psoriasis. Diabetologia, 54 (11). pp. 2745-2754. ISSN 0012-186X
Downer, Eric J. and Clifford, Eileen and Gran, Bruno and Hendrik, J. Nel and Fallon, Padraig G. and Moynagh, Paul N. (2011) Identification of the Synthetic Cannabinoid R()WIN55,212-2 as a Novel Regulator of IFN Regulatory Factor 3 Activation and IFN- Expression. Journal of Biological Chemistry, 286 (12). pp. 10316-10328. ISSN 0021-9258
Mellett, Mark and Atzei, Paola and Jackson, Ruaidhri and O’Neill, Luke A. and Moynagh, Paul N. (2011) Mal Mediates TLR-Induced Activation of CREB and Expression of IL-10. Journal of Immunology, 186 (8). pp. 4925-4935. ISSN 0022-1767
Siednienko, Jackub and Nowak, Joanna and Moynagh, Paul N. and Gorczyca, Wojciech A. (2011) Nitric oxide affects IL-6 expression in human peripheral blood mononuclear cells involving cGMP-dependent modulation of NF-jB activity. Cytokine, 54. pp. 282-288. ISSN 1043-4666
Moynagh, Paul N. (2011) Peli1 (rel)ieves autoimmunity. Nature Immunology, 12 (10). pp. 927-929. ISSN 1529-2908
Hams, Emily and Saunders, Sean P. and Cummins, Eoin P. and O'Connor, Aisling and Tambuwala, Murtaza T. and Gallagher, William M. and Byrne, Annette and Compos-Torres, Antonio and Moynagh, Paul N. and Jobin, Christian and Taylor, Cormac T and Fallon, Padraic G. (2011) The hydroxylase inhibitor DMOG attenuates endotoxic shock via alternative activation of macrophages and IL-10 production by B-1 cells. Shock, 36 (3). pp. 295-302. ISSN 1073-2322
Atzei, Paola and Gargan, Siobhan and Curran, Niamh and Moynagh, Paul N. (2010) Cactin Targets the MHC Class III Protein IκB-like (IκBL) and Inhibits NF-κB and Interferon-regulatory Factor Signaling Pathways. Journal of Biological Chemistry, 285 (47). pp. 36804-36817. ISSN 0021-9258
Atzei, Paola and Yang, Fan and Collery, Ross and Kennedy, Breandan N. and Moynagh, Paul N. (2010) Characterisation of expression patterns and functional role of Cactin in early zebrafish development. Gene Expression Patterns, 10 (4/5). pp. 199-206. ISSN 1567-133X
Moynagh, Paul N. (2009) The Pellino family: IRAK E3 ligases with emerging roles in innate immune signalling. Trends in Immunology, 30 (1). pp. 33-42. ISSN 1471-4906
Cumiskey, D. and Butler, M.P. and Moynagh, Paul N. and O'Connor, J.J. (2007) Evidence for a role for the group I metabotropic glutamate receptor in the inhibitory effect of tumor necrosis factor-α on long-term potentiation. Brain Research, 1136. pp. 13-19. ISSN 0006-8993
Butler, Marion P. and Hanly, Jennifer A. and Moynagh, Paul N. (2007) Kinase-active Interleukin-1 Receptor-associated Kinases Promote Polyubiquitination and Degradation of the Pellino Family : direct evidence for PELLINO proteins being ubiquitin-protein isopeptide ligases. Journal of Biological Chemistry, 282 (41). pp. 29729-29737. ISSN 0021-9258
Miggin, Sinead and Palsson-McDermott, Eva M. and Dunne, Aisling and Jefferies, Caroline and Pinteaux, Emmanuel and Banahan, Kathy and Murphy, Caroline and Moynagh, Paul N. and Yamamoto, Masahiro and Akira, Shizuo and Rothwell, Nancy and Golenbock, Douglas and Fitzgerald, Katherine A. and O'Neill, Luke A.J. (2007) NF-kB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1. Proceedings of the National Academy of Sciences, 104 (9). pp. 3372-3377. ISSN 1091-6490
Sheridan, Graham K. and Pickering, Mark and Twomey, Clare and Moynagh, Paul N. and O'Connor, John J. and Murphy, Keith J. (2007) NF-κB activity in distinct neural subtypes of the rat hippocampus: Influence of time and GABA antagonism in acute slice preparations. Learning & Memory, 14 (8). pp. 525-532. ISSN 1072-0502
O'Sullivan, Niamh C. and McGettigan, Paul A. and Sheridan, Graham K. and Pickering, Mark and Conboy, Lisa and O'Connor, John J. and Moynagh, Paul N. and Higgins, Desmond G. and Regan, Ciaran M. and Murphy, Keith J. (2007) Temporal change in gene expression in the rat dentate gyrus following passive avoidance learning. Journal of Neurochemistry, 101 (4). pp. 1085-1098. ISSN 0022-3042
Griffin, Bryan D. and Moynagh, Paul N. (2006) In vivo binding of NF-κB to the IκBβ promoter is insufficient for transcriptional activation. Biochemical Journal, 400. pp. 115-125. ISSN 0264-6021
Griffin, Bryan D. and Moynagh, Paul N. (2006) Persistent Interleukin-1β Signaling Causes Long Term Activation of NFκB in a Promoter-specific Manner in Human Glial Cells. Journal of Biological Chemistry, 281 (15). pp. 10316-10326. ISSN 0021-9258
Cummins, E.P. and Berra, E. and Comerford, K.M. and Ginouves, A. and Fitzgerald, K.T. and Seeballuck, F. and Godson, C. and Nielsen, J.E. and Moynagh, Paul N. and Pouyssegur, J. and Taylor, C.T. (2006) Prolyl hydroxylase-1 negatively regulates IκB kinase-β, giving insight into hypoxia-induced NFκB activity. Proceedings of the National Academy of Sciences, 103 (48). pp. 18154-18159. ISSN 1091-6490
Hassett, S. and Moynagh, Paul N. and Reen, D. (2006) TNF-α is a mediator of the anti-inflammatory response in a human neonatal model of the non-septic shock syndrome. Pediatric Surgery International, 22 (1). pp. 24-30. ISSN 0179-0358
Carty, Michael and Goodbody, Rory and Schröder, Michael and Stack, Julianne and Moynagh, Paul N. and Bowie, Andrew G. (2006) The human adaptor SARM negatively regulates adaptor protein TRIF–dependent Toll-like receptor signaling. Nature Immunology, 7 (10). pp. 1074-1081. ISSN 1529-2908
Moynagh, Paul N. (2005) The NF-κB pathway. Journal of Cell Science, 118. pp. 4589-4592. ISSN 0021-9533
Butler, Marion P. and Hanly, Jennifer A. and Moynagh, Paul N. (2005) Pellino3 Is a Novel Upstream Regulator of p38 MAPK and Activates CREB in a p38-dependent Manner. Journal of Biological Chemistry, 280 (30). pp. 27759-27768. ISSN 0021-9258
Curran, Niamh and Griffin, Bryan D. and O'Toole, Daniel and Brady, Kevin J. and Fitzgerald, Stephen and Moynagh, Paul N. (2005) The Synthetic Cannabinoid R(+)WIN 55,212-2 Inhibits the Interleukin-1 Signaling Pathway in Human Astrocytes in a Cannabinoid Receptor-independent Manner. Journal of Biological Chemistry, 28 (43). pp. 35797-35806. ISSN 0021-9258
Moynagh, Paul N. (2005) TLR signalling and activation of IRFs: revisiting old friends from the NF-κB pathway. Trends in Immunology, 26 (9). pp. 469-476. ISSN 1471-4906
Moynagh, Paul N. (2005) The interleukin-1 signalling pathway in astrocytes: a key contributor to inflammation in the brain. Journal of Anatomy, 207 (3). pp. 265-269. ISSN 0021-8782
Butler, M.P. and O'Connor, J.J. and Moynagh, Paul N. (2004) Dissection of Tumor-Necrosis Factor-α Inhibition of Longterm Potentiation (LTP) Reveals a p38 Mitogen-Activated Protein Kinase-Dependent Mechanism which Maps to Early - But Not Late-Phase LTP. Neuroscience, 124 (2). pp. 319-326. ISSN 0306-4522
O'Reilly, Susan M. and Moynagh, Paul N. (2003) Regulation of Toll-like receptor 4 signalling by A20 zinc finger protein. Biochemical and Biophysical Research Communications, 303 (2). pp. 586-593. ISSN 0006-291X
Moynagh, Paul N. (2003) Toll-like receptor signalling pathways as key targets for mediating the anti-inflammatory and immunosuppressive effects of glucocorticoids. Journal of Endocrinology, 179 (2). pp. 139-144. ISSN 0022–0795
Butler, Marion P. and Moynagh, Paul N. and O'Connor, John J. (2002) Methods of detection of the transcription factor NF-kB in rat hippocampal slices. Journal of Neuroscience Methods, 119 (2). pp. 185-190. ISSN 0165-0270
Brady, Karen and Fitzgerald, Stephen and Ingvarsson, Sigurdur and Borrebaeck, Carl A.K. and Moynagh, Paul N. (2001) CD40 Employs p38 MAP Kinase in IgE Isotype Switching. Biochemical and Biophysical Research Communications, 289 (1). pp. 276-281. ISSN 0006-291X
Bourke, Emer and Kennedy, Eugene J. and Moynagh, Paul N. (2000) Loss of IκB-β Is Associated with Prolonged NF-κB Activity in Human Glial Cells. Journal of Biological Chemistry, 275 (51). pp. 39996-40002. ISSN 0021-9258
Akesson, A. and Ingvarsson, S. and Brady, K. and Moynagh, Paul N. and Borrebaeck, C.A.K. (2000) Rapid polarization of Th2 cells during induction of antigen-specific IgE antibodies in vitro. Clinical and Experimental Allergy, 30 (9). pp. 1298-1306. ISSN 0954-7894
Brady, Kevin J. and Fitzgerald, Stephen and Moynagh, Paul N. (2000) Tumour-necrosis-factor-receptor-associated factor 6, NF-jB-inducing kinase and IjB kinases mediate IgE isotype switching in response to CD40. Biochemical Journal, 350. pp. 735-740. ISSN 0264-6021
Bourke, Emer and Moynagh, Paul N. (1999) Antiinflammatory Effects of Glucocorticoids in Brain Cells, Independent of NF-kB. Journal of Immunology, 163. pp. 2113-2119. ISSN 0022-1767
Bowie, Andrew G. and Moynagh, Paul N. and O'Neill, Luke A.J. (1997) Lipid Peroxidation Is Involved in the Activation of NF-kB by Tumor Necrosis Factor but Not Interleukin-1 in the Human Endothelial Cell Line ECV304. Journal of Biological Chemistry, 272 (41). pp. 25941-25950. ISSN 0021-9258
